About Immune-D Plus

dog sitting in front of sunset

As dog owners, many of us would agree that our dog is our best friend.  We love our dogs unconditionally and will do whatever it takes to give them the best and healthiest life possible.

Every day, our dogs depend on us to care for them and make the best decisions on what they eat, what exercise they get, and what medical care they receive.  Taking care of our dog is like taking care of a child, as they can only do so much. In return, our dogs sense our love and demonstrate their affection.

With our revolutionary, first ever, breakthrough liquid supplement for dogs, Immune-D Plus™, you can now give your dog their best chance to live a longer, healthier, and more vibrant life by supporting their immune system, the foundation of health in your dog.  How?

Quick Facts About Cancer

  • Cancer is the # 1 disease killer of dogs.
  • Dogs have a 50% chance of being diagnosed with cancer in their lifetime.
  • 6 million dogs get cancer every year in the United States (versus 1.6 million people).
  • Only 400 veterinary oncologists in the U.S. compared with over 23,000 human oncologists.
  • Some types of cancers that dogs get are similar to pediatric cancers in humans – for instance bone cancer, lymphoma, and brain cancer. Dogs also get sarcomas, mammary cancer (similar to human breast cancer in people), and bladder cancer.​
  • We believe that Immune–D will give your dog a chance not to be one of the 50% to get cancer.

According to the National Canine Cancer Foundation, there is a 1 in 3 chance of your dog getting cancer by age 9.  While canine cancer can be treated (with varying success) using surgery, chemotherapy, radiation, and immunotherapy, the best thing you can do is to catch the disease in its early stages before it spreads.  Early detection is critical for successful treatment and recovery.  But what’s even better?  Prevention.

Disease prevention is at our fingertips in the many supplements that are available, but there’s great news…now all of the critical immune support ingredients (trace minerals, vitamins, antioxidants, and amino acids) are available in one daily “shot” called Immune-D Plus™ by Little Big Shots.  Immune-D Plus™ supports a dog’s entire immune system and helps reduce your dog’s risk for disease.

Research and Development

Pursuant to years of research on the lifespan and health of canines, Little Big Shots has created a liquid formula that supports a dog’s immune system with over 130 necessary minerals, antioxidants, amino acids and vitamins.  This proprietary, customized Immune-D Plus™ formula was developed on the simple principle of our founder wanting his two dogs to live a healthier and more vibrant life.  The Immune-D Plus™ formula can conveniently be placed on your dog’s food (or directly in their mouth) once a day to ensure that your pet is receiving the minerals, antioxidants, amino acids and vitamins that are lost in the dry food formation process, and lost when administered in a pill or capsule form (as the body absorbs these critical ingredients in a liquid 85%-90% more than in a pills or capsule).


Our product is 100% natural and is made in a pharmaceutical FDA registered facility.  All formulation certifications have been obtained to ensure the validity of the above comments and you can read our Clinical Data sheets on each powerful ingredient by clicking HERE.

What makes Immune-D Plus™ so uniquely different than your average pet supplement is three-fold: Firstly, as published in the Veterinary Physicians Desktop Reference Guide is the fact that pill supplements have an absorption rate into your pet’s system of 5%-18%.  Therefore, you are wasting valuable nutrients and dollars by administering a supplement pill to your dog, irrespective of what the manufacturer claims. Secondly, Immune-D Plus is the first ever liquid supplement that has an absorption rate of up to 90% with over 130 minerals, antioxidants, vitamins and amino acids.  Thirdly, our liquid is measured into the appropriate ml size for your dog, ensuring that he or she receives the same dose per day. Dogs up to 25 pounds will receive a 6ml daily dose. Dogs weighing 26-69lbs will receive a 9ml daily dose. And for large dogs over 70lbs, Immune-D Plus™ is offered in a 12ml daily dose.
Learn More About How Immune-D Plus™ Works…

Endorsed by Leading Veterinarians and Scientists

Dr. Linus Pauling, a world renowned scientist and recipient of two Nobel Peace Prizes (only one of four people ever to achieve this multiple honor), stated, “You can trace every sickness, every disease and every ailment to a mineral deficiency.” However, minerals, all over the world are disappearing from our soils at alarming rates.  Additionally, many dog owners are under the misconception that they can achieve the highest level of nutrition from the food they feed their dog.  Approximately 85% of all dog food sold in America is dry.  Many of these dog foods claim that they are loaded with the proper nutrients for a dog’s healthy life.  What the dog food companies don’t tell us is that many of the original nutrients placed into large vats prior to the heat transfer process and final manufacturing, causes a massive depletion of key minerals and vitamins.  Hence, your dog eating the minimal nutritious ingredients.


The Ingredients Inside Immune-D Plus™

Read Some Of Our Clinical Studies